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Unit-3, Gastrointestinal Agents (Pharmaceutical Inorganic Chemistry)

The digestive system is the  gastrointestinal tract (GIT) It starts from the esophagus to the anus. The central portion of GIT   includes the stomach,  small intestine, large intestine, and the rectum with the exit anus. 

 

Whenever the functions of  GIT go wrong, disease occurs. Ingestion of Food Transportation of Food Digestion of food from Complex to simpler form Absorb essential nutrients into the circulatory system Excrete out waste product from the body Inadequate secretion of acid in the stomach causes achlorhydria or hypochlorhydria. 

When excess acid secretion occurs in the stomach, this causes an imbalance of the acid–enzyme ratio, which causes hyperacidity or ulcer. 

There may occur accumulation of toxic substances or gases. There may occur inadequate absorption of fluids and minerals from the large intestine, which causes diarrhea. Insufficient peristaltic movement of the large intestine may occur, causing constipation. There may be inadequate secretion of saliva, making the food difficult to swallow. Ingestion of poisonous substances may occur accidentally or intentionally by some person. It is possible to correct the above conditions by administering suitable drugs, called the Gastrointestinal Agents

 

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